Idiopathic nephrotic syndrom of the childhood and its treatment
Idiopathic nephrotic syndrome is a chronic glomerular disorder seen in childhood. The first objective in the management of this disorder is to induce remission to resolve proteinuria and edema. In these cases the most common cause is minimal change disease (MCD). The majority of patients respond to corticosteroid therapy. Steroid sensitive nephrotic syndrome usually has good prognosis and 80% of cases go into remission by puberty. The frequently relapsing nephrotic syndrome requires other treatment options. The purpose of these treatments is to induce remission and to provide steroid sparing effect. These agents include cancer agents like cyclophosphamide, transplant medication like cyclosporin, and immunomodulators like levamisole. The success with these medications is variable and their side effect profiles are unique.