SCREENING DOWN SYNDROME WITH NUCHAL TRANSLUCENCY
The most frequently used antenatrel test performed is made for screening Down syndrome. The syndrome, described first by Langdon Down in 1866, is the most commonly seen chromosomal abnormality in live births. In 1980s, the syndrome was screened by only maternal age, then the triple test was used. In early 1990s, it was observed that there is increased nuchal thickness in the first trimester ultrasound of fetuses with Down syndrome. After years of research, a first trimester screening test with nuchal thickness as the main parameter is actually under use in many centers worldwide. This review examines this first trimester screening test, based on the combination of fetal nuchal thickness, maternal age and maternal serum biochemistry at 10-14 weeks of gestation.